Do you know the way to San Jose - Dionne Warwick
Driving My Life Away - Eddie Rabbit

Oh and

Beep Beep - the Playmates (my Dad had every Goofy Greats/Funky Favorites KTel ablums ever made)

By the time I get to Phoenix - Glen Campbell

Trans Europe Express - Kraftwerk
Driving - Pearl Harbor and the Explosions
Pink Cadillac - Brice Springstein
Cars - Gray Neuman
Rockin' Down the Highway - Doobie Brothers
Los Angeles - X
Talking Heads - Take me To THe River
Traveling Light - Tindersticks
Holiday in Cambodia - Dead Kennedys

Bitchin Camero - Dead Milkmen

Autobahn - Kraftwerk
Warm Leatherette - The Normal
Road Runner - Sid Vicious version from the Great Rock & Roll Swindle
Riding on the Metro - Berlin
Bahnhof Zoo - Nina Hagen
Ford Mustang - Serge Gainsburg & Jane Birkin
My Baby Takes the Morning Train - Sheena Easton
Cities - Talking Heads
I'm on the Road to Nowhere - Talking Heads

Boat of Car - TMBG
Road Movie to Berlin - TMBG

Tenuous link (involve "going" but no vehicle)
Devil went down to Georgia - Charlie Daniels Band (No imposters!)
Cowtown - TMBG (guess which band's been getting heavy rotation in the Prudence household lately!)
The KKK Took My Baby Away - Ramones

Guilty pleasures I'll never admit to owning:
Talk Dirty to Me - Poison
Come Sail Away - Styx

Oh, and "The Wheels on the Bus" by any number of artists...

As much as I love TMBG, and although this fits the theme, I wouldn't put it on a road-trip mix. You'll drive too slowly.