I don't really care where I stay. The rooms at pretty much any on strip hotel are fine by my standards (now that the Boardwalk is gone; and note, by my standards a Motel 6 room is more luxury than I really need) and even the $28/night hotels off Fremont downtown work for me.
I've never flown to Vegas so I always have a car, though I generally take a cab everywhere anyway.
MBC, since you're at that end of the strip I heartily recommend a visit to
Luv-It Frozen Custard. Very good stuff.