[Strangler Lewis]

Define safe. Define inexpensive. The Hyatt Union Square typically has internet specials for the mid $100s. The Rex Hotel in the classy west-of-Tenderloin area on Sutter Street is neat. I've never stayed there, but I've gone to parties in the bar. I checked rates there recently, and I think it's mid 100s. It's an old style building, so you won't have much of a view once you're in for the night. There are a bunch of other hotels on Sutter as well that might fit the bill.