I've stayed at
this one many, many times. It's nice, and it's right on Market. There's a Muni/Bart station entrance right out front.
It's owned by Ramada (and until recently, was called the Ramada Plaza). The building was built as a temporary city hall in 1911 (there are still jail cells in the basement!). It opened as the Hotel Whitcomb in 1915. I'm glad Ramada decided to go back to the historic name.