I have the big brother to the Toshiba. I went with the Regza line because they are optimized for Hi-Def movies. For example, they have a 120Hhz refresh rate and a 24fps mode. Blu Ray and HD movies are encoded at 24fps and playback in that mode is smoother (less jaggies) than at the standard 60fps. In MI:III there is a scene where they walk down a flight of marble stairs. In 60fps mode you see jaggies but in 24 it's smooth as silk. That's just one example. If you like movies make sure the sharp can match the detailed specs of the Toshiba (and that the 42" version you are looking at has these features....).
I will note that out of the box the Toshiba had some color issues (a noticeable green push) but with a bit of tweaking it's now spot on. Plan to spend some time with a utility like
Avia no matter which set you purchase.
With
blu ray players going for under $300 I would STRONGLY suggest AGNIST the Oppo at this point. They have has their day. A blu ray player will upscale as good or better than the Oppp and give you all that Disney hi def goodness. Pirates is simply stunning in Blu! Of course you will still have the multi-region issues.
Oh and don't be freaked when movies (standard or Hi-Def) still have the black bars at the top and bottom. Unfortunately that's normal on these sets (both the Toshiba and the Sharp).
If you do go HD I would also reccomend
Blue Jeans Cables for all your cable needs.
And if you REALLY want to obsess over this decision visit
here and
here.