I think "weakness" is fine but it requires contest when used alone as an absolute it becomes a problem even in the most Darwinian examples. Certain "diseases" (e.g. Sickle Cell Anemia) while a potential weakness today were a strength before modern medicine caught up with the genetics.
Saying something is a weakness does nothing to further the dialogue on what to do or react to a particular condition, Rather it comes off as a dismissive way of saying, "that's not my problem."
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I would believe only in a God that knows how to Dance.
Friedrich Nietzsche
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