Note (since I clarified after I posted): I do not know of a way to ASSEMBLE the images in Acrobat (it may be doable, though I doubt it), I just recommend Acrobat for the OUTPUT.
Photoshop or GIMP areprobably you best bets for image assembly. Note that when working with large images, it will be RAM intensive. I suggest starting with inner-most image and working your way out. Don't try to assemble blocks and then going back to assemble the blocks - things may not line up properly.
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