If you compare left handed scissors to right, they're flipped. The top blade passes on the outside (when held in the hand it's designed for) of the bottom blade. If you use the wrong hand, the lateral force exerted by your fingers as you squeeze will cause the blades to want to separate.
On a really well put together pair, that really won't matter and you can use it with either hand since the joint is probably solid enough that the slight lateral force isn't enough to really separate the blades any. But that still leaves one other disadvantage. If you're using righty scissors with your left hand, the top blade will be on the inside, obscuring your line of sight, so you won't be able to see exactly what you're cutting.
I think way too much about scissors apparentyl
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