I'm not going to say there is a solid line. But Kirk's motiviations and Spock's motivations for how they proceed through life have been fundamentally changed. And whether that results in somewhat similar courses that is, in my opinion, a very important difference.
But the key thing is not just that they are different people than originally depicted but that with this film we are told that all that has come before is irrelevant (and I believe one of mousepod's points is that it is cheating to use the love of what has come before as the draw to get you into the theater only to reveal halfway in that it is all being discarded) to any future engagement with the franchise except insofar as it allows the writers a convenient shortcut. Yes, those events still happened in some other timeline (similar to "its just a dream events" really happened in the dream) but they are of no future use in experiencing future events (except where they provide easy one-liners to future writers).
I also don't understand at all the comparison to James Bond beyond the fact that they are really the only examples of such lengthy movie franchises. I'm sure you really do see a parallel of importance but I'm completely missing it since the internal structure of the two franchises has never been on similar terms.
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