I must second EH's recommendation for the Frick - it's (frickin'

) amazing!
Central Ppark and the Met are 2 of my favourite places in the entire world. The Rose Centre for Space (or whatever it's called) at the Museum of Natural History is pretty cool, as are the dinosaur exhibits. I also love wandering up through soHo to Union Square - it's a nice, interesting walk, with plenty to check out on the way.
Have fun!
