Though I disagree with the argument, the protesters against these things (and they protested Cassini as well) haven't ever argued that the odds of a specific mission causing trouble is very small that as the number of missions accumulate the odds of something disastrous happening becomes more and more likely.
However, since I am a huge proponent of vastly increased use of nuclear power on Earth, I'm not really bothered by the relatively infinitesimal risk of plutonium cargo on space missions.
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