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I've never had a desire to try such things.
Having been sedated and drugged many times over the last couple of years due to medical reasons, I honestly do not know why anyone would enjoy the feeling of being drugged. It just makes me feel.....icky. I don't enjoy loosing control over my faculties, and like Alex stated, I like the way my brain operates without trying to alter it.
I cannot imagine that any mind altering drug is particularly good for you regardless of frequency. I suppose caffeine through chocolate is about the only drug I put into my body willingly (with the exception of pain killers following surgery, and i didn't like those a bit).
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