I've heard that a lot of software isn't working on Vista...XP had the same issue when it came out. Biggest program I can think of is iTunes, though Apple said they will release a new version which makes it compatible in the next few weeks.
I toyed with the idea of putting Vista on my Mac, but I don't really see a reason to. It doesn't offer any real improvments that I've been able to see over some flashy new graphics, and I've heard that it is really unreliable and buggy. If you decide not to go with a Mac, I would wait until Vista SP1 or SP2 came out. They will fix a lot of the bugs.
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